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BioMed Research International .PMID 26090416Read source (2016)

Most commonly, underlying chronic venous insufficiency is the culprit, but they can also be the result of trauma, chemotherapy, autoimmune disorders, and corticosteroid administration

Shelf Life: Up to 2 years unopened, advised to use within 28 days if opened

Cleanse, apply copper peptide serum, moisturize