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Early reports that Kupffer cell-induced oxidant stress and peroxynitrite formation may cause APAP-induced injury [92, 93] were questioned as the data could not be reproduced [9496], NADPH oxidase-deficient mice were not protected [97, 98] and mitochondria in centrilobular hepatocytes were identified as the main source of superoxide and peroxynitrite under these conditions [72, 99]
CrossRef Reversed role of CD36 deficiency in high-fat diet or methionine/choline-deficient diet-induced hepatic steatosis and steatohepatitis Wenya Zhu, Jialing Ma, Tingting Zhang, Mengmeng Zhu, Yajun Duan, Xiaoxiao Yang, Yuanli Chen Frontiers in Pharmacology .2025;[Epub] CrossRef Hepatocyte nuclear factor 4-Alpha: a key regulator in liver carcinogenesis Hayam Hamdy, Chang Shen, Jiashun Xu, Die Fan, Yiwen Zhang, Hui Li, Yonglong Wei, Jianwei Sun Cellular Oncology .2025
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