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Researchers use it to probe cofactor requirements of dehydrogenases, assess redox balance in cell systems, and examine NAD+-dependent enzyme families (e.g., sirtuins and ADP-ribosylation processes) under well-defined conditions

IDH1 inhibition potentiates chemotherapy efficacy in pancreatic cancer

Upon depolarization of astrocytes, molecules such as AQP4 that normally localize in endfoot membranes are redistributed to non-endfoot membranes, thereby compromising AQP4 function 24

Studies in the Journal of Applied Physiology show that exogenous IGF-1 alone produces measurable increases in muscle protein synthesis (2030% above baseline) even without concurrent GH elevation, provided insulin sensitivity is normal

Clinical trials show that GLP-1 drugs produce significantly greater weight loss compared to metformin alone