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A significant limitation to the clinical use of cytisine is its poor ability to cross the BBB, which is considerably lower than that of nicotine or varenicline (Gotti and Clementi, 2021)

However, there were no significant group-by-time interactions in PANAS

Abstract Background The Ehlers-Danlos syndromes (EDS) are rare connective tissue disorders consisting of 13 subtypes with overlapping features including joint hypermobility, skin and generalized connective tissue fragility

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Nicotine present in cigarettes relaxes the lower esophageal sphincter (LES), thereby allowing acid to escape into the esophagus