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Unlike traditional peptide compounds that target a single receptor pathway, Retatrutide functions as a triple receptor agonist, interacting with GLP-1 (Glucagon-Like Peptide-1), GIP (Glucose-Dependent Insulinotropic Polypeptide), and glucagon receptors

Berberine makes more sense as a metabolic-support option for people who are not on a GLP-1 and are working on insulin resistance, not as a companion to one

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