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In the kidney, GLP-1RAs directly induce natriuresis and diuresis by acting on the proximal convoluted tubule (PCT) through inhibition of sodium-hydrogen exchanger 3 (NHE3)

[DOI] [PubMed] [Google Scholar] 67.Ochner CN, Barrios DM, Lee CD, Pi-Sunyer FX

Chang may adjust your dosage or recommend practical solutions, such as dietary modifications, hydration strategies, or appropriate medications

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If you find that gentle methods and lifestyle changes aren't providing relief, it is a sign to seek professional advice rather than reaching for stronger, potentially problematic laxatives