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Verkhivker GM, et al

Additionally, inhibiting Gln metabolism can reverse chemotherapy resistance

In view of this continuity, the following discussion traces these events as a mechanistic cascade, starting with defective ERmitochondria calcium coupling, continuing through redox injury and impaired mitochondrialysosome quality control, and then considering interfaces that govern polarity, metabolism, transcriptional adaptation, and inflammatory amplification

Essential vitamins, such as E, A and C, as well as polyphenols and melatonin contribute to the neutralization of ROS and support cellular repair mechanisms

PMID: 22005198