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Recently, metabolites derived from probiotics have emerged as novel adjunctive agents that can inhibit adherence, reduce hyphal development, disrupt biofilm structure, decrease virulence, and potentially impact persister-like subpopulations

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While insulin and IGF-1 share structural similarities and activate overlapping intracellular signaling pathways, such as the PI3K/Akt and MAPK pathways, they exhibit differential localization within the brain, which may impact their distinct roles in neuronal function and mood regulation [94, 95]

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It activates ghrelin receptors in the pituitary gland to stimulate growth hormone secretion