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doi: 10.1038/nrneph.2015.3 96 WuXYouDPanMWengMXieQGuanYet al

The key site for lipid and glucose metabolism, calcium homeostasis, detoxifying drugs, and metabolisms is the central processing unit responsible for protein translation, folding, and modification ( UPR is mediated by a partner molecule specific for the endoplasmic reticulum, namely glucose-regulated protein78(GRP78), and three transmembrane protein stress sensors ( Figure 3 )

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Rather than relying on systemic distribution to deliver neuroprotective compounds to the brain, CAQK homes specifically to injured brain tissue when administered intravenously

Patients should be empowered to play an active role in their treatment plan, collaborating with their healthcare team to develop personalized strategies for managing the transition