Journal of Clinical Medicine , 12
Very common (10% of patients) Nausea peaks during titration, typically subsides within 48 weeks at a stable dose Vomiting, diarrhoea, constipation Abdominal pain or discomfort Reduced appetite (this is the therapeutic effect, not an adverse effect) Less common but serious stop and see a doctor Severe, persistent abdominal pain radiating to the back possible pancreatitis Right upper abdomen pain, fever, yellowing possible gallstones / gallbladder disease Persistent neck lump, hoarseness, difficulty swallowing evaluate thyroid Rapid heartbeat, severe dehydration from vomiting Hypoglycaemia when semaglutide is combined with insulin or sulfonylureas What the Indian data shows: a 2025 study of Indian patients found GI side effects are the leading cause of discontinuation, peaking during dose escalation

Cancer Sci 109:611617 Mauseth B, Camilio KA, Shi J, Hammarstrm CL, Rekdal , Sveinbjrnsson B, Line P-D (2019) The novel oncolytic compound LTX-401 induces antitumor immune responses in experimental hepatocellular carcinoma
2 Increases Natural Energy Levels Helps stay active and alert throughout the day
Who should not take Akkermansia