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Brunkow, Fred Ramsdell and Shimon Sakaguchi discovered how the "immune system is kept in check," identifying regulatory T-cells (or T-regs), which prevents immune cells from attacking our own body
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On the other hand, viral protein sequences could form complexes with porphyrin, affect heme on the 1- chain of Hb, and release free iron 147
Consequently, diminished Treg-derived IL-10 and TGF- release leads to uncontrolled Th2 activation
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