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Combining the changes in the three groups, at the genus level, Clostridium_sensu_stricto_1 was increased in the TS group compared to the CON group, and GABA treatment alleviated the Clostridium_sensu_stricto_1 abnormality, suggesting a potential mechanism (Figure 2D)
These models demonstrate the distinct temporal and pathological progression of AD ike features, including tau abnormalities, intraneuronal A accumulation, and synaptic and neuronal loss, making them valuable tools for studying disease mechanisms and therapeutic strategies
We treated TC1-6 cells with serum collected from WT or GCGR-KO mice for 72 h and found that VGF and proglucagon protein levels were significantly increased in GCGR-KO serum-treated cells (Fig
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