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Evert AB, Boucher JL, Cypress M, Dunbar SA, Franz MJ, Mayer-Davis EJ, et al

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Semaglutide has consistently demonstrated better reductions in HbA1c and body weight compared to placebo and a variety of active comparators, including sitagliptin, exenatide extended release, insulin glargine, dulaglutide, canagliflozin, and liraglutide

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They are both GLP-1 receptor agonists, which means that they work by mimicking hormones in the brain and digestive system that regulate appetite, feeling of fullness, and the movement of food through the stomach and intestines