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The dose-response relationship between smoking and cardiovascular mortality is non-linear, suggesting that reduction in HPHC concentrations in e-cigarette aerosols may not result in proportional harm reduction and decreased HPHC exposure may be offset by increased use by individuals who believe that e-cigarettes are safer than conventional cigarettes

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There was a downside to all that weight gain, in that they were more likely to develop type 2 diabetes over the medium term, but they were still at lower risk of premature death overall