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F15.20 covers amphetamine, methamphetamine, MDMA (ecstasy), and caffeine, as well as other non-cocaine stimulants not classified elsewhere

"Many signals tied into developmental pathways," said the study's lead author Dr Bonnie Joubert, an epidemiologist at the US National Institute of Environmental Health Sciences (NIEHS), noting that changes were seen in genes relating to lung and nervous system development, smoking-related cancers, and birth defects such as cleft lip and cleft palate

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Crowe nails the performance by not hamming-up the character, but rather by understating his personality