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A previous study demonstrated that combining multiple modes of 1064-nm Nd: YAG laser treatment resulted in higher melasma clearance rates and lower relapse rates after 1 year of follow-up 12

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TRPM2 expression is positively correlated with M2 macrophages, which are tumor-promoting and linked to immunosuppression, rather than M1 macrophages, which have tumor-suppressing functions

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