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Also, for antineoplastic drugs, the results of the review indicate a reduction in the effective concentration and a reduction in the bodys exposure to the drug in smokers, involving the induction of various hepatic enzymes of the cytochrome P450 family: CYP1A1, CYP1A2 and CYP2E1 [15, 19, 24,25,26,27]

* Difference between this estimate and the 2012 estimate is statistically significant at the .05 level

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AF-CSC-60C(10SP) Integrated