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Although glutathione can be obtained from foods, dietary intake is not very effective because it gets broken down in the digestive system

in contrast, GSS knockout depletes GSH but still permits glutamate consumption for -glutamyl-peptide synthesis, and does not alter ferroptosis sensitivity under cystine starvation

Asia Pacific Glutathione Market Outlook, By Product Form, Value (US$ Mn) and Volume (Tons), 2019 - 2032 8.2.1

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While these signs can hint at low glutathione, they are not definitive