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Accordingly, in some embodiments, cyclodextrins are included to increase the solubility of the therapeutic agents, or auris-acceptable otic agents, within the formulations or compositions described herein

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Glutathione peroxidases (GSH-Pxs) constitute a family of antioxidant enzymes primarily present in eukaryotic organisms, which utilize GSH as a cofactor to catalyze the reduction of H 2 O 2 .These enzymes play a crucial role in antioxidant defense mechanisms and are potentially involved in immune responses against pathogenic infections [10]

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