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While adding further variables may reduce the power to detect associations, it is important to establish true, unbiased associations, particularly in complex disease where several small effects may contribute to the disease

However, our large study found no evidence to support those theories. Among people smoking 20 or more cigarettes a day, menthol smokers were approximately 12 times more likely to develop lung cancer than never-smokers, while non-menthol smokers were about 21 times more likely to have the disease

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As part of the standard-setting process, FDA would be required to take into account the technical feasibility of compliance, as well as the existence of any patents that might make it impossible to meet a compliance deadline