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Herbal preparations that affect blood glucose levels, such as ginseng, fenugreek, or bitter melon, may have additive glucose-lowering effects when combined with semaglutide, potentially increasing the risk of hypoglycemia particularly in patients receiving other antidiabetic medications

Thus, EV-associated miRNAs in follicular fluid likely contribute to PCOS pathogenesis by altering granulosa cell functions, though their regulatory mechanisms require further exploration

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