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These mutations are caused by increased host susceptibility (due to genetic factors) and by carcinogens that bind to DNA
Study characteristics, including geographical location (continents), ethnicity, gender, country income level, study quality, outcome definition, the proportion of current and female smokers, sample size and year, were utilised for explanatory meta-regression models (Table S8)
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HTPs were first introduced to the Italian market in November 2014 9
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