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They also found that PNE increased the expression of the D5 dopamine receptor in the striatum but did not influence exploratory locomotion, the delay-discounting test, or the expression of other dopamine-related genes ( DRD4 , DAT1 , NR4A2 , and TH ) in either the PFC or the striatum [80]

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Stokes, Fetterman, Benjamin, Bhatnagar, Hamburg, and Blaha are all also affiliated with the American Heart Association Tobacco Regulation and Addiction Center.

Toddlers "explore their environment by putting things in their mouth" and may mistake flavored liquid nicotine for candy, Smith said, noting that creating child-resistant containers and educating parents about the dangers of these substances is key to keeping children safe

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