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Heteroplasmy of mouse MtDNA is genetically unstable and results in altered behavior and cognition [J]

Additional ICD-10 codes may be required to capture underlying diseases, related disorders, or contributing conditions, following the correct sequencing and reporting guidelines

Nature 551(7682):648652 Drannik A, Martin J, Peterson R, Ma X, Jiang F, Turnbull J (2017) Cerebrospinal fluid from patients with amyotrophic lateral sclerosis inhibits sonic hedgehog function

Contingent on promising early results, a major clinical trial (Phase 3) is conducted with hundreds to thousands of patients to confirm the treatments efficacy