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135 AIM2 deficiency, another sensor involved in inflammasome activation, enhances APAP-induced inflammation and acute liver injury in aged mice by promoting oxidative stress and phosphorylation of JNK

Available online at: (Accessed September 7, 2025)

To address this, future interventions should prioritize integrated synbiotic therapies, combining carefully selected probiotics with specific prebiotics to enhance microbial engraftment, stabilize gut ecology, and reinforce host metabolic and immune homeostasis (Balthazar et al., 2022)

Methods : Evidence were searched by means of boolean operators and cross references in databases MEDLINE, LILACS and Google Scholar

One weekly injection with a slow, personalized titration schedule managed by your clinician, plus regular check-ins to keep momentum and comfort balanced