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The increased intracellular ATP consumption, increased tissue oxygen consumption and oxidative phosphorylation, overexpression of adrenergic receptors, and a decrease in antioxidant defensive mechanisms are the mechanisms of free radicals overproduction that favour OxS in hyperthyroid patients (46)

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In contrast to chemotherapy, which is administered systemically, radiotherapy is applied locally, significantly reducing the likelihood of damage to healthy tissues [90] (Fig

Glutathione is used as a major component of cell culture media like RPMI-1640, McCoy's 5A media, Medium 199 and some of the MCDB media