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This escalation should only occur if the lower dose is well-tolerated and additional benefit is needed to achieve treatment goals
Vassimon HS, Deminice R, Machado AA, Monteiro JP, Jordao AA
It is worth noting that one of the recently approved ALS therapies (sodium phenylbutyrate + TUDCA, as mentioned earlier) highlights the intersection of microbiome-related metabolism and neurodegeneration [224]
A systematic review of 35 studies found consistent age-related GSH decline in blood and specific brain regions, including the precuneus, hippocampus, cingulate, and frontal cortex
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