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Ethical approval The study was approved by the SingHealth Centralised Institutional Review Board (CIRB No: 2023/2636) on 30 November 2023

Important structural and functional changes in synaptic plasticity and neural connectivity occur in different brain regions in adolescence (72, 74, 109)

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These grim statistics highlight the need for new tobacco control initiatives

Both nicotine and smoke-related toxins, such as PAHs, have complex pharmacodynamic effects in cancer treatment, with interactions between apoptosis, tumour angiogenesis, host immune function and chemosensitivity [42]