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It is intriguing that, despite the coexistence of both COX-1 and COX-2 in HCAEC, histamine is able to segregate its influence on COX-2/PGE 2 /PGI 2 pathway and not on COX-1/TXA 2 pathway

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Cohens hotspot method was complimentary to the algorithm selection process as hotspot-identified windows reduce the dimensionality of the data, using only the pertinent sections of clinical notes instead of the entire note