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The slowing of gastric emptying, whilst beneficial for blood sugar control and satiety, can initially cause the digestive system to adjust, leading to nausea and related symptoms

Author contributions S.A.G

Oral B12 supplementation is more accessible and cost-effective but relies on gastric intrinsic factor for absorption, rendering it unsuitable for individuals with gastric disorders or malabsorption syndromes

This is why almost all clinical peptides (insulin, GLP-1 agonists, growth hormone, the whole class) are injected

The full analysis was presented at the European Association for the Study of Diabetes 2025 Annual Meeting in Austria