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AMs exhibit heterogeneous phenotypes under pathological conditions ( This review focuses on the phenotypes and function states of AMs associated with the pathogenesis of COPD, as well as the specific mechanisms underlying their heterogeneous immunometabolism patterns, referred to as metabolic reprogramming, hoping to be exploited to develop potential therapeutic ideas for COPD

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Overall smoking prevalence and e-cigarettes use trends Figure 1 shows the trends in current (at least monthly) and daily smoking prevalence and prevalence of current (at least monthly) and daily use of ECs each year between 2011/12 and 2020/21