Patients receiving B12 injections should inform their healthcare provider of all medications, as certain drugs (including metformin, proton pump inhibitors, and chloramphenicol) can affect B12 absorption or metabolism
Annals of Clinical & Laboratory Science, 45(4), 426-432
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B12 Shots for Weight Loss: Is There a Difference
Unlike fat-soluble vitamins (A, D, E, and K), which are stored in fat tissue for long periods, water-soluble vitamins are processed relatively quickly: your body takes what it needs, stores a small amount in the liver, and passes most of the rest in urine