1 cigarette a day reduces your life 🩺 Stop smoking by age 35, and cancer risk drops to nearly the same as someone who never smoked — experts say your body can actually reverse the damage. Pioneering research shows quitting by 44 One cigarette may seem small…

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Fragmented sleep Smokers tend to have fragmented sleep that leads to insomnia, take slightly longer to fall asleep (sleep latency), enjoy less deep sleep (slow-wave sleep), experience more sleep disruptions, and frequently complain about difficulty in either falling asleep or staying asleep, even though smoking makes them tired

Since SIRT6 has context-dependent (dose-, tissue-, model-dependent) roles in the brain, these findings should be viewed as a plausible, theoretical mechanistic pathway

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Furthermore, tobacco smoking disrupted gut microbiota composition and hepatic metabolism, increasing cholesterol accumulation and altering bile acid homeostasis, particularly under high-fat diets