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GLP-1 (Glucagon-like peptide-1) receptor agonists like semaglutide (Wegovy) and tirzepatide (Mounjaro) work by regulating appetite and reward pathways in the brain

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The core message is blunt and aimed squarely at current smokers and their clinicians: The primary public health message of our paper is the importance of complete smoking cessation at younger ages. Cutting back from a pack a day to a few cigarettes a day does reduce risk, but this new analysis shows that even those few cigarettes still carry substantial danger, and that simply reducing intensity is a poor substitute for stopping altogether