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Similarly, in vivo and in vitro data also support that acute exposure to aerosolized PG:VG increases Mucin-5AC (MUC5AC) protein levels [34], a major airway gel forming protein known for its role in preventing infections [35] and a biomarker for COPD severity [36]

Moffatt RJ, Biggerstaff KD, Stamford BA

METHODS Literature search A systematic search was conducted across PubMed (14 April 2024), Cochrane Library (58 April 2024), Embase (15 May 2024), and Web of Science (610 May 2024), using MeSH terms and free-text keywords related to nicotine replacement therapy, smokeless tobacco, cessation, and reduction

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