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In severe cases, individuals may experience difficulty sleeping, performing daily activities, or lifting heavy objects

Clinical-trial use is not the same as unsupervised use

H.ChoiD.-H.KimK.-S.OhW.-K.et al (2015)

In general, by either excess or impairment, NO appears to cause or contribute to a variety of disturbances, in particular, hypertension, angina, impotence, circulatory shock, septic shock, stroke, inflammation, respiratory distress syndromes, pulmonary hypertension, adhesion and aggregation of platelets and leukocytes, diabetes, hypotension, and Parkinson's disease

Common side effects include hypoglycemia, nausea, and diarrhea