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Again, these higher expression levels observed in APP/PS1 animals suggests a genotype-related transcriptional regulation, which may be related to increased hippocampal oxidative stress in transgenic animals (Aso et al., Whether this regulated Gpx4 mRNA variant constitutes an intermediate processing stage of Gpx4 splicing or represents a different level of transcriptional regulation by intron retention remains unrevealed

El glutatin responde a estas condiciones como parte de un sistema adaptativo

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Feeding the copper chelator bis-cyclohexanone-oxalyldihydrazone (cuprizone, CTZ) reduces the myelin sheath and activates microglial and astroglial cells in the CNS, providing a reproducible and reversible model of pathologic processes underlying white and gray matter demyelination [296,297,298,299,300,301]

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