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Its hard to quantify the exact conversion as factors like

The idea is, instead of sear first then finish in the oven, you smoke it first at a low temperature to get the smoky flavor, and then finish it by searing (either on a grill or hot stovetop skillet) for the beautiful and flavorful crust

Increased oxidative stress and disrupted small intestinal tight junctions in cigarette smoke-exposed rats

Menthol was exempted from these flavour restrictions, as were larger cigars and other tobacco products

Sustained NRF2 activation probably contributes to persistent antioxidant defense and cellular resilience during long-term oxidative challenge, consistent with observations that NRF2 signaling remains constitutively active in smoking-associated squamous carcinomas 29,30