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Crossing the BBB is particularly advantageous in malignancies such as glioblastoma multiforme (GBM), where diffuse infiltration and chemoresistance hinder surgical and pharmacological management
To meet the diagnostic criteria for spEDS, a person must meet major criterion 1 AND major criterion 2 AND have characteristic radiographic abnormalities AND at least two other minor criteria (general or gene-specific)
always keep the vial protected from direct light between uses
The choice between medications should rest primarily on efficacy data, tolerability, availability, and cost rather than the B12 inclusion, which is valuable in both formulations
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