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After identifying any MDMR regions, we then conducted follow-up seed-based connectivity (see ROI-Based Connectivity Analysis ) analysis to examine the spatial distribution of these connectivity differences as in prior MDMR analyses ( Importantly, MDMR identifies regions where connectivity correlates to a phenotype (e.g., daily cigarette consumption, cigarettes/day) but this initial analysis does not identify the direction of correlation or the spatial pattern

Menthol cigarette use also was correlated with more lifetime psychiatric hospitalizations in a study of young adult smokers with severe mental illness