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"However this methodology does provide a good estimate for those that are chronic users of a certain substance, as it is based on average usage and life expectancy data."

moderate certainty), but may result in little to no harm from other adverse events, such as hiccups, gastrointestinal disturbances, skin irritation from patches, throat irritation, or runny nose.43 Varenicline results in small harms from increases in nausea (32 RCTs, n = 14 963

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Two of the most effective prescription medications for smoking cessation are Varenicline and Bupropion