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Tirzepatide is a novel dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist approved by the FDA for two primary indications: type 2 diabetes mellitus (marketed as Mounjaro) and chronic weight management (marketed as Zepbound)

To measure the effect of GLP-1R in CM, a selective GLP-1R agonist (liraglutide) and an antagonist (exendin(939)) were applied in the experiment

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For example, the FDAs ban on mixed semaglutide, effective April 22, is expected to limit access to affordable medications and impact the compounded semaglutide price for weight loss