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Tissue cultures were then randomly assigned to three primary treatment groups: physiological control (5.5 mM glucose, 5% O 2 ), CSE-treated (5.5 mM glucose + 10% CSE, 5% O 2 ), or low-nutrient conditions (1.5 mM glucose, 1% O 2 )

Competing interests The authors of the manuscript declare no conflicts of interest and take sole responsibility for the writing and content of the manuscript

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