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Some research has shown that berberine can modestly increase GLP-1 secretion in the gut when taken orally

The PH domain of 2 and 3 plays a dual role, much like PLC-1, by binding to the plasma membrane, as well as being a site of interaction for the catalytic activator

ORCID: Affiliation: 13 Department of Biochemistry, Institute of Chemistry, University of So Paulo, Cidade Universitria, So Paulo CEP 05508-000, SP, Brazil These authors contributed equally to this work

The serotonin connection Serotonin plays a central role in mood regulation, and GLP-1 receptor activation directly influences serotonergic signaling

10.1136/gutjnl-2016-311921 Gut 86 KimJ