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The relationship between choline bioavailability from diet, intestinal microbiota composition, and its modulation of human diseases

However, the iron-chelator deferoxamine (DFO) did not affect APR-246 activity (Supplementary Fig

Although neither compound showed effects against disease onset and progression at moderate dosage levels, the combination of sodium salicylate and para-aminobenzoic acid, as well as larger doses of sodium salicylate by itself, seemed to delay onset, lessen incidence, and inhibit disease severity if administration was begun prior to or shortly after (5 days or less) EAE induction [149]

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