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News provided by Perricone MD Jan 13, 2026, 09:44 ET SAN FRANCISCO, Jan

The cataplerotic reactions that involve conversion of PEP to pyruvate in the cytosol then pyruvate to oxaloacetate (OAA) then OAA to aspartate in the mitochondria then aspartate back to OAA in the cytosol and OAA back to PEP constitute what is referred to as pyruvate cycling

More research is needed to fully comprehend their potential benefits and risks

The breakdown of histamine is a multi-step process governed primarily by two enzymes: Diamine Oxidase (DAO), which degrades extracellular histamine in the gut, and Histamine N-methyltransferase (HNMT), which neutralizes intracellular histamine in the liver and central nervous system

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