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doi:10.1161/CIRCULATIONAHA.113.006416

Its not about getting the good feeling anymore its about relieving the bad feelings of not having enough drug in the system. Grieder hopes the discovery of the brain mechanism behind nicotine aversion, provided it is similar in humans, will open the door to finding a more effective treatment for smokers who want to quit

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Facts about tobacco, heart and other cardiovascular diseases Cardiovascular diseases (CVD) kill more people than any other cause of death worldwide, and tobacco use and second-hand smoke exposure contribute to approximately 17% of all heart disease deaths