However, the Direct distribution channel , which encompasses brand-owned websites, DTC subscription services, and marketplace storefronts, has been gaining share at an accelerating pace, representing approximately 27.6% of total revenues in 2025 compared to approximately 17.8% in 2020
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Although long-term users of ENDS products may show similar endothelial function compared to non-smokers, some studies suggest these endothelial changes as post-use effects ( 69 )
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