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Over time, this challenges the logic of lifelong polypharmacy across large patient populations

Trial design: 751 adults with obesity (BMI 30, or 27 with at least one comorbidity) No type 2 diabetes 72-week follow-up Tirzepatide 10mg or 15mg vs Semaglutide 2.4mg Results at 72 weeks: When looking at tirzepatide weight loss results from SURMOUNT-5 alongside semaglutide weight loss results from the STEP trials, the gap is consistent and statistically significant across every subgroup sex, age, baseline BMI, and presence of metabolic comorbidities

[DOI] [PMC free article] [PubMed] [Google Scholar] 63.Hamilton D, Jian HW, Batist G

It contains 0.9% benzyl alcohol, which inhibits bacterial growth in the solution