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The main carcinogens in chewing tobacco are tobacco-specific nitrosamines (TSNAs)

There is evidence that its use is associated with certain cancers, diseases of the mouth and nicotine addiction, and long-term use may increase the risk of death from stroke. The researchers statistical analysis of participants data made adjustments for factors such as age, gender, cardiovascular disease diagnoses and body mass index

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Associations between oral hygiene habits, diet, tobacco and alcohol and risk of oral cancer: A casecontrol study from India

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